A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.
نویسندگان
چکیده
Starting from an HTS derived hit 1, application of biostructural data facilitated rapid optimization to lead 22, a novel AMPA receptor modulator. This is the first demonstration of how structure based drug design can be exploited in an optimization program for a glutamate receptor.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 20 19 شماره
صفحات -
تاریخ انتشار 2010